反応 #3945

反応方程式

2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

hydrogen peroxide

→

2-(2-Methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.STIRRINGIt is then stirred until a precipitate
2. 2
   その他has formed
3. 3
   ろ過This is subjected to suction filtration
4. 4
   その他purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)]

実験手順

An amount of 0.21 gm of 2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is suspended in 10 ml of glacial acetic acid and mixed with 0.08 ml of 30% hydrogen peroxide. The mixture is stirred for 24 hours at ambient temperature and poured onto 20 ml of ice water. It is then stirred until a precipitate has formed. This is subjected to suction filtration and purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)].

出典