反応 #3938

反応方程式

thiourea

sodium hydroxide

triethylamine

1-cinnamyl-4-(3-chloropropyl)piperazine dihydrochloride

→

3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride

収率 52.0%

溶媒

water

ethanol

反応条件

実験手順

The procedure described in Example 1(b) was followed, using 3.1 g of thiourea, 7.4 g of 1-cinnamyl-4-(3-chloropropyl)piperazine dihydrochloride, 4,1 g of triethylamine and 100 ml of reagent ethanol. The hydrolysis was effected with 3.0 g of sodium hydroxide in 30 ml of water. Work-up, as described above, gave 3.6 g (52% of theory) of 3-(4-cinnamylpiperazin-1-yl)propanethiol dihydrochloride as a white crystalline solid, M.p. 249°-252° C.

出典