反応 #3936
ord-79c508329b5d4f1d8bd9e814f1079ea1
反応方程式
n-hexyl isocyanate
3-{4-[4-(4-chlorophenyl)butyl]piperazin-1-yl}propanethiol
→
N-(n-hexyl)-S-{3-[4-[4-(4-chlorophenyl)butyl]piperazin-1-yl]propyl}thiocarbamate dihydrochloride
収率 99.8%
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
The procedure described in Example 2 was followed, using 1.0 g of n-hexyl isocyanate, 2.6 g of 3-{4-[4-(4-chlorophenyl)butyl]piperazin-1-yl}propanethiol and 25 ml of methylene chloride, to give 1.4 g (32% of theory) of N-(n-hexyl)-S-{3-[4-[4-(4-chlorophenyl)butyl]piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 235°-245° C. (dec.).