反応 #3934

反応方程式

4-(4-chlorophenyl)butyl piperazine

1-bromo-3-chloropropane

potassium hydroxide

→

1-[4-(4-chlorophenyl)butyl]-4-(3-chloropropyl)piperazine dihydrochloride

収率 125.7%

溶媒

dimethyl sulfoxide

反応条件

実験手順

The procedure described in Example 1(a) was followed, using 10.0 g of 4-(4-chlorophenyl)butyl piperazine, 47.2 g of 1-bromo-3-chloropropane, 150 ml of dimethyl sulfoxide and 11.2 g of potassium hydroxide, to give 10.0 g (82% of theory) of 1-[4-(4-chlorophenyl)butyl]-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid, M.p. 266°-268° C.

出典