反応 #3933

ord-b3cce434c6ef4afc85c9dbb95a837744

反応方程式

CCCCCCN=C=O
n-hexyl isocyanate
SCCCN1CCN(Cc2ccc(Cl)cc2)CC1
3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol
CCCCCCNC(O)=[SH]CCCN1CCN(Cc2ccc(Cl)cc2)CC1.Cl.Cl
N-(n-hexyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride
収率 157.9%

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The procedure described in Example 35 was followed, using 1.4 g of n-hexyl isocyanate, 3.0 g of 3-[4-(4-chlorobenzyl)piperazin-1-yl]propanethiol and 100 ml of methylene chloride, to give 2.7 g (51% of theory) of N-(n-hexyl)-S-{3-[4-(4-chlorobenzyl)piperazin-1-yl]propyl}thiocarbamate dihydrochloride as a white crystalline solid, M.p. 249°-252° C. (dec.).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04722926uspto-grants-1988_02