反応 #3915

反応方程式

thiourea

sodium hydroxide

triethylamine

1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride

→

3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride

収率 176.1%

溶媒

water

ethanol

反応条件

実験手順

The procedure described in Example 1(b) was followed, using 1.3 g of thiourea, 6.4 g of 1-(4-chlorophenethyl)-4-(3-chloropropyl)piperazine dihydrochloride, 1.6 g of triethylamine and 150 ml of reagent ethanol. The hydrolysis was effected with 3.5 g of sodium hydroxide and 40 ml of water. Work-up, as described above, gave 5.6 g (89% of theory) of 3-[4-(4-chlorophenethyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 279°-281° C.

出典