反応 #3911

反応方程式

1-phenethyl piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride

収率 188.8%

溶媒

dimethyl sulfoxide

反応条件

実験手順

The procedure described in Example 1(a) was followed, using 29.4 g of 1-phenethyl piperazine, 25.0 g of potassium hydroxide, 100 ml of dimethyl sulfoxide and 24.0 g of 1-bromo-3-chloropropane. Work-up, as described above, gave 32.6 g (64% of theory) of 1-phenethyl-4-(3-chloropropyl)piperazine dihydrochloride as an off-white crystalline solid.

出典