反応 #3903

反応方程式

1-bromo-3-chloropropane

1-(4-methylbenzyl)piperazine

potassium hydroxide

dimethyl sulfoxide

→

1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

溶媒

Water

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred for an additional hour
2. 2
   抽出the product was extracted with ether
3. 3
   乾燥the extract was dried (sodium sulfate)
4. 4
   workup.ADDITIONtreated with ethereal hydrochloric acid

実験手順

A mixture of 14.0 g of 1-(4-methylbenzyl)piperazine, 8.0 g of potassium hydroxide and 125 ml of dimethyl sulfoxide was stirred for 45 minutes. 11.8 g of 1-bromo-3-chloropropane were then added, and the mixture was stirred for an additional hour. Water was added, and the product was extracted with ether, and the extract was dried (sodium sulfate) and treated with ethereal hydrochloric acid to give 23.3 g (94% of theory) of 1-(4-methylbenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

出典