反応 #3888

反応方程式

1-(4-chlorobenzyl)piperazine

potassium hydroxide

1-bromo-3-chloropropane

→

1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride

収率 74.0%

溶媒

dimethyl sulfoxide

反応条件

実験手順

Utilizing the procedure described in Example 1(a), 20.0 g of 1-(4-chlorobenzyl)piperazine, 100 ml of dimethyl sulfoxide, 15.0 g of potassium hydroxide and 15.0 of 1-bromo-3-chloropropane yielded 25.1 g (74% of theory) of 1-(4-chlorobenzyl)-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

出典