反応 #3885

反応方程式

1-bromo-3-chloropropane

1-benzylpiperazine

dimethyl sulfoxide

potassium hydroxide

→

1-benzyl-4-(3-chloropropyl)piperazine dihydrochloride

収率 163.9%

溶媒

Water

反応条件

後処理

1. 1
   抽出the reaction product was extracted with ether
2. 2
   乾燥dried (magnesium sulfate)
3. 3
   その他the salt was precipitated with ethereal hydrochloric acid

実験手順

31.5 g of 1-bromo-3-chloropropane were added to a mixture of 35 g of 1-benzylpiperazine, 150 ml of dimethyl sulfoxide and 25 g of potassium hydroxide. The resulting mixture was stirred at room temperature for 3 hours. Water was added to the resulting solution, the reaction product was extracted with ether, dried (magnesium sulfate), and the salt was precipitated with ethereal hydrochloric acid to give 35.6 g (55% of theory) of 1-benzyl-4-(3-chloropropyl)piperazine dihydrochloride as a white crystalline solid.

出典