反応 #3883

ord-5cde0d6b47b04ae18f76dd684a697a17

反応方程式

COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
title compound
COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
t-butoxycarbonyl-D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide
C1COCCO1.Cl
hydrogen chloride dioxane
→
COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](N)CCSC.COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](N)CCSC.Cl.Cl.O
D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride hemihydrate

反応物

COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
title compound
COC(=O)CCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CCSC)NC(=O)OC(C)(C)C
t-butoxycarbonyl-D-methionylglycyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide
C1COCCO1.Cl
hydrogen chloride dioxane

試薬

なし

溶媒

C1COCCO1
dioxane

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他the volatiles were removed in vacuo
  2. 2
    その他the residue triturated thoroughly with diethyl ether
  3. 3
    その他The title compound (10.9 g) was collected as an analytically pure hydrochloride hemihydrate

実験手順

The title compound of Example 10 (12.0 g) was dissolved in 50 ml of dioxane to which was added 50 ml of 6M hydrogen chloride/dioxane. After about one hour, the volatiles were removed in vacuo and the residue triturated thoroughly with diethyl ether. The title compound (10.9 g) was collected as an analytically pure hydrochloride hemihydrate.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04722922uspto-grants-1988_02