反応 #3880

反応方程式

title compound

t-butoxycarbonyl-N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide

hydrogen chloride dioxane

→

title compound

N-(6-methoxy-6-oxohexyl)-L-phenylalaninamide monohydrochloride

溶媒

dioxane

反応条件

後処理

1. 1
   濃縮After about 30 min. the solution was concentrated in vacuo to dryness
2. 2
   その他the residue triturated thoroughly with diethyl ether
3. 3
   その他The solid was collected
4. 4
   洗浄washed well with diethyl ether

実験手順

To a solution of the title compound of Example 2 (43.1 g, 0.11 mole) in 100 ml of dioxane was added 100 ml of 6M hydrogen chloride/dioxane. After about 30 min. the solution was concentrated in vacuo to dryness and the residue triturated thoroughly with diethyl ether. The solid was collected and washed well with diethyl ether, giving 34.7 g of the title compound, which was used in subsequent reactions without further purification.

出典