反応 #3872

反応方程式

potassium hydroxide

7-hydroxy-3-piperidino-2,2-dimethylbenzofuran

1,4-dibromobutane

→

desired product

7-(4-Bromobutoxy)-3-piperidino-2,2-dimethylbenzofuran

溶媒

ether

ether

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   抽出extracted with 5% aq. HCl
3. 3
   洗浄the acidic phase washed with ether
4. 4
   その他The acidic phase is made basic thereby forming an oil which
5. 5
   洗浄washed with sat'd aq. NaCl
6. 6
   その他dried
7. 7
   ろ過filtered
8. 8
   その他evaporated in vacuo

実験手順

Crushed potassium hydroxide (19.6 g) and tetrabutyl ammonium chloride (1.7 g) are added to a solution of 7-hydroxy-3-piperidino-2,2-dimethylbenzofuran (14.4 g) in 1,4-dibromobutane (69.4 ml) and the mixture stirred at RT under nitrogen for 5 hours. The reaction mixture is diluted with ether, washed with water, extracted with 5% aq. HCl and the acidic phase washed with ether. The acidic phase is made basic thereby forming an oil which is taken up in ether, washed with sat'd aq. NaCl, dried, filtered and evaporated in vacuo affording the desired product as a liquid.

出典