反応 #3871

反応方程式

1,3-dibromopropane

Potassium hydroxide

H2O

product

7-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

→

desired product

7-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

溶媒

diethyl ether

ether

反応条件

後処理

1. 1
   洗浄washed with 5% aq. HCl
2. 2
   洗浄The acidic solution is washed with ether
3. 3
   その他basified, affording an oil which
4. 4
   洗浄washed with sat'd NaCl
5. 5
   その他dried
6. 6
   ろ過filtered
7. 7
   その他evaporated in vacuo

実験手順

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

出典