反応 #3864

反応方程式

potassium hydroxide

product

6-Hydroxy-4-piperidino-2,3-dihydrobenzopyran

1,3-dibromopropane

→

desired product

6-(3-Bromopropoxy)-4-piperidino-2,3-dihydrobenzopyran

溶媒

ether

diethyl ether

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   抽出extracted into 5% aq. HCl
3. 3
   洗浄The aqueous solution is washed with ether
4. 4
   その他yielding a yellow oil which
5. 5
   洗浄washed
6. 6
   その他dried
7. 7
   ろ過filtered
8. 8
   その他evaporated

実験手順

Crushed potassium hydroxide (1.15 g) and tetrabutyl ammonium chloride (0.61 g) are added to a solution of the product obtained in Step 3. (4.8 g) in 1,3-dibromopropane (21 ml). The reaction mixture is stirred under nitrogen at RT for 48 hours, diluted with diethyl ether, washed with water and extracted into 5% aq. HCl. The aqueous solution is washed with ether and made alkaline yielding a yellow oil which is taken up in ether, washed, dried, filtered and evaporated to give the desired product as an oil.

出典