反応 #3855

反応方程式

hydrogen

N-(2-amino-2-methylpropyl)-1,2-ethanediamine

2-butanone

→

N-(2-butyl)-N'-(2-amino-2-methylpropyl)-1,2-ethanediamine

収率 69.5%

溶媒

methanol

反応条件

後処理

1. 1
   温度After two hours the reaction mixture was cooled
2. 2
   ろ過filtered
3. 3
   その他to remove the catalyst
4. 4
   その他to give 205.3 g of water-white clear liquid which
5. 5
   workup.DISTILLATIONwas fractionally distilled under reduced pressure
6. 6
   その他The desired product recovered
7. 7
   その他a boiling point (b.p.) of 62°-64° C./0.15 mm Hg

実験手順

A mixture of 146 g (1.1 moles) of N-(2-amino-2-methylpropyl)-1,2-ethanediamine, 84.4 (1.17 moles) of 2-butanone, 300 ml methanol, and 3.0 g of 10% platinum on carbon were reacted in a 1 liter autoclave at 80° C. under 800 pounds per square inch (psi) hydrogen pressure. After two hours the reaction mixture was cooled, then filtered to remove the catalyst. The filtrate was stripped to give 205.3 g of water-white clear liquid which was fractionally distilled under reduced pressure. The desired product recovered was found to weigh 144.5 g (69.5% yield), and has a boiling point (b.p.) of 62°-64° C./0.15 mm Hg.

出典