反応 #379

反応方程式

COC(=O)c1ccc(I)cc1O

CC(C)(C)OC(=O)N1CCNC

→

COC(=O)c1ccc(N2CCN(C

溶媒

COCCOC

反応条件

実験手順

tert-butyl piperazine-1-carboxylate (0.670 g, 3.60 mmol) and methyl 2-hydroxy-4-iodobenzoate (1 g, 3.60 mmol), BINAP (0.224 g, 0.36 mmol), cesium carbonate (2.461 g, 7.55 mmol) were put inDME (18 mL), tris(dibenzylideneacetone)dipalladium(0) (0.165 g, 0.18 mmol) was added last. Reaction wsa purged by nitrogen, and heated at90 °C overnight. No desired product was found.

出典