反応 #3750

反応方程式

hydrochloric acid

1,3-Di-n-propyl-6-aminouracil

acetic acid

Sodium nitrite

→

1,3-di-n-propyl-5-nitroso-6-aminouracil

収率 146.3%

溶媒

water

water

反応条件

後処理

1. 1
   その他A purple precipitate formed
2. 2
   workup.ADDITIONAddition
3. 3
   workup.STIRRINGto stir for 2 hours
4. 4
   ろ過The solution was then filtered
5. 5
   洗浄the filtrate was rinsed with water
6. 6
   その他dried under vacuum

実験手順

1,3-Di-n-propyl-6-aminouracil (30 g) was suspended in 1 L of water with 41 ml of 20% acetic acid and overhead stirring. Sodium nitrite (9.03 g) in 41 ml of water was added in portions, keeping the solution acidic with 12 ml of concentrated hydrochloric acid. A purple precipitate formed. Addition was complete in 10 minutes and the suspension was allowed to stir for 2 hours. The solution was then filtered, and the filtrate was rinsed with water and dried under vacuum to yield 46 g of 1,3-di-n-propyl-5-nitroso-6-aminouracil.

出典