反応 #3740

反応方程式

2-amino-2-cyanoacetamide

trimethylorthoformate

n-Propylamine

→

title compound

収率 61.1%

5-Amino-1-n-propylimidazole-4-carboxamide

収率 61.1%

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 0.75 hour
3. 3
   温度to cool
4. 4
   その他The solid which precipitated
5. 5
   ろ過was collected by filtration
6. 6
   その他crystallised from methanol

実験手順

A mixture of 2-amino-2-cyanoacetamide (2.8 g, 0.0282 mol), trimethylorthoformate (3.4 g, 0.0321 mol) and acetonitrile (55 ml) was heated under reflux for 0.75 hour, then allowed to cool. n-Propylamine (1.8 g, 0.0305 mol) was then added dropwise, and the resulting mixture stirred at ambient temperature for 36 hours. The solid which precipitated was collected by filtration and crystallised from methanol to give the title compound as a colourless solid (2.9 g, 61%), m.p. 241°-243° C. Found: C,49.67; H,7.15; N,33.64. C7 H12N4O requires C,49.98; H,7.19; N,33.31%.

出典