反応 #3739

反応方程式

sodium dithionite

sodium nitrite

1,3-dicyclopropylmethyl-6-amino-uracil

formamide

formic acid

→

1,3-Di-cyclopropylmethyl xanthine

反応条件

実験手順

1,3-Di-cyclopropylmethyl xanthine was prepared using an analogous procedure to that described in Chem. Berichte 88, 1306-1312, 1955: 20.2 g (0.0855 mol) of 1,3-dicyclopropylmethyl-6-amino-uracil was dissolved in 100 ml of formamide, then 5.9 g sodium nitrite was added and at 60° C. 13.4 ml formic acid was added slowly with stirring. After the colour had changed from yellow to violet, the mixture was heated up to 100° C. and 3.1 g of sodium dithionite (Na2S2O4) was added in small portions.

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