反応 #3733

反応方程式

1,3-Di-n-butyl-8-bromo xanthine

piperidine

→

title product

1,3-Di-n-butyl-8-piperidino Xanthine

溶媒

toluene

反応条件

後処理

1. 1
   温度was refluxed for 9 hours
2. 2
   抽出The reaction mixture was then extracted with water (4×30 ml)
3. 3
   乾燥the organic layer dried over anhydrous sodium sulphate
4. 4
   その他the solvent removed in vacuo
5. 5
   その他The residue was recrystallised from ethanol

実験手順

1,3-Di-n-butyl-8-bromo xanthine (2 g, 0.0029 mol) was dissolved in toluene (50 ml). After addition of piperidine (5 g, 0.0058 mol) the mixture was refluxed for 9 hours. The reaction mixture was then extracted with water (4×30 ml), the organic layer dried over anhydrous sodium sulphate and the solvent removed in vacuo. The residue was recrystallised from ethanol to give the title product, yield 0.4 g (20%), m.pt. 221° C.

出典