反応 #3726

反応方程式

1,3-Di-n-butyl-8-nitro xanthine

1,3-Di-n-butyl-8-nitro Xanthine

tin

hydrochloric acid

→

1,3-Di-n-butyl-8-amino Xanthine Hydrochloride

反応条件

後処理

1. 1
   ろ過Thereafter the precipitate was filtered off
2. 2
   その他recrystallised twice from ethanol
3. 3
   その他The product formed colourless crystals, yield 5.5 g (63%) m.pt >250° C.

実験手順

1,3-Di-n-butyl-8-nitro xanthine from Example 1 (8.5 g) was suspended in concentrated hydrochloric acid (85 ml) and then treated at room temperature with tin powder (14.5 g) in small portions. After stirring for 10 minutes the yellow colour of the suspension disappeared. Thereafter the precipitate was filtered off and recrystallised twice from ethanol. The product formed colourless crystals, yield 5.5 g (63%) m.pt >250° C.

出典