反応 #3714

反応方程式

(2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone

3-trifluoromethyl-cyclohexanone

dimethylaminomethylene chloride

→

( 27 )

(1RS,2RS ,5RS)-3-(2-dimethylaminomethyl-1-hydroxy-5-trifluoromethyl-cyclohexyl)-phenol hydrochloride

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The 5-epimer (27) of compound (25) was prepared, under the conditions

実験手順

The 5-epimer (27) of compound (25) was prepared, under the conditions given in Example 27, from (2RS,5RS)-2-dimethylaminomethyl-5-trifluoromethyl-cyclohexanone, prepared from 3-trifluoromethyl-cyclohexanone and dimethylaminomethylene chloride in acetonitrile. (27) was obtained in a yield of 27% theoretical and had a melting point of 221°-223° C.

出典