反応 #3707
ord-1b59e09c326a4a03910529e081276b80
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度is refluxed for 3 hours
- 2その他The reaction mixture is evaporated in vacuo
- 3その他to remove the CH3OH
- 4抽出The aqueous phase is extracted with CH2Cl2
- 5その他The resulting solid is collected
- 6その他dried under vacuum
実験手順
A mixture of 18.78 g of methyl 4-[2-(2-chlorophenyl)-2-oxoethyl]benzoate in 288.8 ml of CH3OH, 72.2 ml of water and 5.2 g of NaOH is refluxed for 3 hours then acidified with 2N citric acid. The reaction mixture is evaporated in vacuo to remove the CH3OH. The aqueous phase is extracted with CH2Cl2 and acidified with 1N HCl. The resulting solid is collected and dried under vacuum to give 17.27 g of the desired product, m.p. 168°-172° C.