反応 #3681

反応方程式

3-fluoro-2-methylbenzoic acid

thionyl chloride

→

3-fluoro-2-methylbenzoyl chloride

反応条件

後処理

1. 1
   その他the excess thionyl chloride removed under vacuum
2. 2
   workup.ADDITIONTo the residue is added toluene (several times)
3. 3
   その他the toluene removed under vacuum
4. 4
   workup.ADDITIONafter each addition

実験手順

A solution of 2.87 g of 3-fluoro-2-methylbenzoic acid in 25 ml of thionyl chloride is refluxed for 1.75 hour and the excess thionyl chloride removed under vacuum. To the residue is added toluene (several times) and the toluene removed under vacuum after each addition to give 3-fluoro-2-methylbenzoyl chloride.

出典