反応 #3680

反応方程式

ethyl 4-aminobenzoate

N-chlorosuccinimide

→

ethyl 3-chloro-4-aminobenzoate

収率 73.9%

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度is refluxed overnight
2. 2
   洗浄The mixture is washed with saturated NaHCO3 solution
3. 3
   乾燥dried (Na2SO4)
4. 4
   洗浄the filter cake washed with dichloromethane
5. 5
   濃縮The filtrate is concentrated
6. 6
   workup.ADDITIONhexane added
7. 7
   温度Chilling

実験手順

A mixture of 8.26 g of ethyl 4-aminobenzoate, 8.26 g of N-chlorosuccinimide in 50 ml of dichloromethane is refluxed overnight. The mixture is washed with saturated NaHCO3 solution and dried (Na2SO4). The solution is passed through a thin pad of hydrous magnesium silicate and the filter cake washed with dichloromethane. The filtrate is concentrated and hexane added. Chilling gives 7.38 g of ethyl 3-chloro-4-aminobenzoate, m.p. 82°-83° C.

出典