反応 #367284

反応方程式

sodium fluoride

ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate

→

ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate

収率 90.0%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度under reflux for 2 hours
2. 2
   workup.ADDITIONwhile hot, poured onto ice
3. 3
   ろ過The precipitate is filtered off with suction
4. 4
   洗浄thoroughly washed with water
5. 5
   乾燥dried over calcium chloride at 100° C. in vacuo

実験手順

21.2 g of sodium fluoride are added to a solution of 107.8 g of ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-cyclopropylaminoacrylate in 400 ml of anhydrous dimethylformamide. The reaction mixture is then stirred under reflux for 2 hours and, while hot, poured onto ice. The precipitate is filtered off with suction, thoroughly washed with water and dried over calcium chloride at 100° C. in vacuo. 91.2 g of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate of melting point 167°-168° C. are obtained.

出典