反応 #366916

反応方程式

2-phenoxyphenylsulfonamide

n-hexyl isocyanate

1,4-diazabicyclo-[2,2,2]-octane

trichloromethyl chloroformate

→

2-phenoxyphenylsulfonylisocyanate

収率 82.6%

溶媒

xylene

xylene

反応条件

後処理

1. 1
   その他At the end of the reaction
2. 2
   workup.DISTILLATIONthe xylene and n-hexyl isocyanate were distilled off

実験手順

25.0 g of 2-phenoxyphenylsulfonamide, 14.0 g of n-hexyl isocyanate, a catalytic amount of 1,4-diazabicyclo-[2,2,2]-octane and 150 ml xylene were refluxed with stirring for an hour. Thereafter, the mixture was reacted with a solution of 11.9 g of trichloromethyl chloroformate in 30 ml of xylene in a manner similar to that of Example (1). At the end of the reaction, the xylene and n-hexyl isocyanate were distilled off, to obtain 22.8 g of 2-phenoxyphenylsulfonylisocyanate. B.p. 146°-150° C./0.7 mmHg.

出典