反応 #3662

反応方程式

2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione

N-formylhydrazine

→

gray solid

収率 37.3%

4,5-Dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine

収率 37.3%

溶媒

n-butanol

反応条件

後処理

1. 1
   温度refluxed for 18 hours
2. 2
   その他the solvent removed under vacuum
3. 3
   workup.ADDITIONIce water is added to the residual solid
4. 4
   ろ過the mixture filtered

実験手順

A mixture of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione (0.8 g) and 0.80 g of N-formylhydrazine in 8 ml of n-butanol is stirred and refluxed for 18 hours and the solvent removed under vacuum. Ice water is added to the residual solid and the mixture filtered to give 0.312 g of a gray solid, m.p. 162°-165° C.

出典