反応 #366147

反応方程式

2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione

3-methylpiperidine

→

title compound

収率 86.9%

2-Benzyloxy-5-bromo-6-(3-methyl-piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione

収率 86.9%

溶媒

DMF

反応条件

後処理

1. 1
   その他The reaction was reacted at 120° C. for 5 hours
2. 2
   温度cooled
3. 3
   濃縮concentrated under vacuum
4. 4
   その他The resulting residue was purified by column chromatography on silica gel

実験手順

To a solution of 2-benzyloxy-5-bromo-6-nitro-benzo[de]isoquinoline-1,3-dione (0.50 g, 1.2 mmol, from Example S1-A) in DMF (5 mL) was added 3-methylpiperidine (0.47 g, 4.7 mmol). The reaction was reacted at 120° C. for 5 hours, cooled, and concentrated under vacuum. The resulting residue was purified by column chromatography on silica gel using hexane/ethyl acetate (5:1) to give 0.50 g of the title compound.

出典