反応 #366020

反応方程式

butyllithium

diisopropylamine

tetrahydrofuran

4-methylphenylphosphine

2,4,6-trimethylbenzoyl chloride

THF

→

bis(2,4,6-trimethylbenzoyl)-4-methylphenylphosphine

溶媒

hexane

反応条件

後処理

1. 1
   その他the solvent is removed under reduced pressure

実験手順

A solution of 16.2 g of diisopropylamine in 50 ml of tetrahydrofuran (THF) is cooled to −10° C. 100 ml of butyllithium in hexane (1.6 M) are added dropwise. Then, at −40° C., first 9.0 g of 4-methylphenylphosphine and, subsequently, a solution of 29.22 g of 2,4,6-trimethylbenzoyl chloride in 150 ml of THF are added. The solution is stirred for 1.5 hours and then the solvent is removed under reduced pressure, to give 28.0 g of bis(2,4,6-trimethylbenzoyl)-4-methylphenylphosphine as a yellow powder.

出典