反応 #365644

反応方程式

2-Hydroxyoctanoic acid

hydrogen chloride methanol

→

methyl 2-hydroxyoctanoate

反応条件

後処理

1. 1
   その他the reaction mixture was evaporated under reduced pressure
2. 2
   その他The residue was partitioned between ethyl acetate and water
3. 3
   洗浄The organic layer was washed with aqueous NaHCO3 solution
4. 4
   乾燥dried over sodium sulfate
5. 5
   その他Evaporation of the solvent under reduced pressure

実験手順

2-Hydroxyoctanoic acid (1.0 g) was stirred in 10% hydrogen chloride methanol solution (20 ml) at room temperature. After 1.5 hours, the reaction mixture was evaporated under reduced pressure. The residue was partitioned between ethyl acetate and water. The organic layer was washed with aqueous NaHCO3 solution and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave methyl 2-hydroxyoctanoate (0.684 g) as a colorless oil.

出典