反応 #365507

反応方程式

NaOH

ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-piperidinecarboxylate

Methanol

→

3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-piperidinecarboxylic acid

溶媒

THF

反応条件

後処理

1. 1
   その他The resulting reaction mixture

実験手順

3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-1-3-piperidinecarboxylic acid as prepared starting from ethyl 3-{[4-(2-butynyloxy)phenyl]sulfonyl}-1-(4-chlorobenzyl)-3-piperidinecarboxylate (1.64 g, 3.3 mmol) dissolved in THF:Methanol (15:50 ml) and NaOH (15 ml). The resulting reaction mixture was worked up as outlined in example 1 (step 7); Yield 1.11 g (75%), white solid: mp 115.2° C.; MS (ES): m/z 462.1 (M+H)+

出典