反応 #364877

反応方程式

water

2-methyl benzimidazole

KOH

methyl iodide

→

1,2-dimethyl benzimidazole

収率 54.2%

溶媒

acetone

反応条件

後処理

1. 1
   workup.ADDITIONwas added at a continuous drip for 0.5 hours, at room temperature
2. 2
   抽出the reaction extracted with dichloromethane
3. 3
   その他evaporated
4. 4
   その他chromatographed on silica gel

実験手順

To 10 grams of 2-methyl benzimidazole (75 mM), crushed 25 grams of crushed KOH (450 mM) in 300 ml acetone, methyl iodide (15 grams, 105 mM) was added at a continuous drip for 0.5 hours, at room temperature. Following additional 0.5 hour, water was added, the reaction extracted with dichloromethane, evaporated and chromatographed on silica gel to yield 6 grams (54%) of 1,2-dimethyl benzimidazole as a white solid having a melting point of 102° C.

出典