反応 #364153

反応方程式

5-methylsalicylaldehyde

malonic acid

pyridine

aniline

→

6-methyl-2-oxo-2H-1-benzopyran-3-carboxylic acid

溶媒

water

ethanol

反応条件

後処理

1. 1
   抽出extracted with ether
2. 2
   その他The solvent is removed by distillation under reduced pressure
3. 3
   その他The residue obtained
4. 4
   その他is recrystallized from ethanol

実験手順

2 g of 5-methylsalicylaldehyde (14.7 mmol), 3.06 g of malonic acid (29.4 mmol), 1.3 g of pyridine and 0.08 g of aniline are dissolved in a minimum amount of ethanol. The mixture is heated at 40° C. on a water bath for 6 h. Next, it is diluted with water, acidified and then extracted with ether. The solvent is removed by distillation under reduced pressure. The residue obtained is recrystallized from ethanol.

出典