反応 #363672

反応方程式

(1R)-1-Isopropyl-2-hydroxyethylamine

SOCl2

2-Methyl-4-nitrophenyl isothiocyanate

→

(4R)-2-(2-methyl-4-nitrophenylimino)-4-isopropyl-1,3-thiazolidine

反応条件

実験手順

(1R)-1-Isopropyl-2-hydroxyethylamine was reacted with SOCl2 followed by 2-Methyl-4-nitrophenyl isothiocyanate according to Method C2a to give (4R)-2-(2-methyl-4-nitrophenylimino)-4-isopropyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4R)-2-(2-methyl -4-nitrophenylimino)-4-isopropyl-3-isobutyl-1,3-thiazolidine.

出典