反応 #363667

反応方程式

(1S)-1-(Hydroxymethyl)-2-methylbutylamine

4-Nitro-1-naphthylamine

2-hydroxyethylamine

4-nitro-1-naphthyl isothiocyanate

(L)-isoleucine methyl ester

4-Nitro-1-naphthyl isothiocyanate

→

(4S)-2-(4-nitro-1-naphthylimino)-4-(2-butyl)-1,3-thiazolidine

反応条件

実験手順

(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Nitro-1-naphthylamine was converted to 4-nitro-1-naphthyl isothiocyanate according to Method A2b. 4-Nitro-1-naphthyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-nitro-1-naphthylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-nitro-1-naphthylimino)-4-butyl-3-isobutyl-1,3-thiazolidine.

出典