反応 #363344

反応方程式

phosphine

benzaldehyde

2-amino-3-picoline

aniline

bezoic acid

1-hexene

toluene

→

heptanophenone

phosphine

反応条件

後処理

1. 1
   workup.ADDITIONwere introduced into each reactor
2. 2
   workup.STIRRINGwith stirring
3. 3
   その他After completion of the reaction, gas chromatography

実験手順

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, 2-amino-3-picoline 0.1 mmol, aniline 0.3 mmol, bezoic acid 0.03 mmol, 1-hexene 2.5 mmol, toluene 0.87 mmol), the mixture in a 500 ml pressure reactor was stirred at normal temperature for 2-3 minutes and then [Rh(C8H14)2Cl]2 0.01 mmol and various phosphine ligands 0.025 mmol as shown in the following table 7 were introduced into each reactor. While the reactor was stopped with a stopper, the reactants were heated at 130° C. for 1 hour with stirring. After completion of the reaction, gas chromatography was conducted to determine the yields of heptanophenone, products from various phosphine ligands. The results are given in Table 7, below.

出典