反応 #363342

反応方程式

benzaldehyde

2-amino-3-picoline

bezoic acid

1-hexene

toluene

→

heptanophenone

反応条件

後処理

1. 1
   workup.ADDITIONwere added to each 500 ml pressure reactor
2. 2
   workup.STIRRINGwith stirring
3. 3
   その他After completion of the reaction, column chromatography

実験手順

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, 2-amino-3-picoline 0.1 mmol, bezoic acid 0.03 mmol, 1-hexene 2.5 mmol, toluene 0.87 mmol), various kinds of amines 0.3 mmol as shown in the following table 5, were added to each 500 ml pressure reactor. The mixture was stirred at normal temperature for 2-3 minutes and then combined with Rh(PPh3)3Cl 0.01 mmol. While the reactor was stopped with a stopper, the reactants were heated at 130° C. for 1 hour with stirring. After completion of the reaction, column chromatography was conducted to determine the yields of heptanophenone, products according to various amines. The results are given in Table 5, below.

出典