反応 #3632

反応方程式

9,10-dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine

2-methylbenzoyl chloride

triethylamine

→

desired product

N-[4-(4H-Furo[2,3-e]pyrrolo[1,2-a][1,4]diazepin-10(9H)-ylcarbonyl)phenyl]-2-methyl benzamide

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄The reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine
2. 2
   乾燥The reaction mixture is dried with Na2SO4
3. 3
   ろ過filtered
4. 4
   その他evaporated in vacuo
5. 5
   その他to give a solid which
6. 6
   その他is purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent

実験手順

To a stirred solution of 1.1 mmol of 2-methylbenzoyl chloride in 10 ml of methylene chloride is added 1.5 mmol of triethylamine. To the mixture is added 1.1 mmol of 9,10-dihydro-10-(4-aminobenzoyl)-4H-furo[2,3-e]pyrrolo[1,2-a][1,4]diazepine and the mixture is stirred for 5 hours. The reaction mixture is washed with water, 1N citric acid, NaHCO3, and brine. The reaction mixture is dried with Na2SO4, filtered and evaporated in vacuo to give a solid which is purified by flash chromatography on silica gel with ethyl acetate-hexane as solvent to give the desired product as a solid.

出典