反応 #362874

反応方程式

2

3-bromo-5-(3,4-dichlorophenyl)-4-amino-pyridine

3-aminoheptane

BINP

NaOtBu

→

5-(3,4-dichlorophenyl)-3-aminoheptane 4-amino-pyridine

溶媒

toluene

反応条件

後処理

1. 1
   その他is consumed
2. 2
   温度The reaction is then cooled to room temperature
3. 3
   洗浄washed 3 times with 10 ml saturated brine
4. 4
   乾燥dried over MgSO4, and condensed in vacuo
5. 5
   その他The crude product is purified by flash chromatography
6. 6
   その他to afford 3

実験手順

A mixture of 2 (1 mmol), 3-aminoheptane (1.2 mmol), Pd2(DBA)3 (0.02 mol, 4 mol % Pd, 18 mg), BINP (0.04 mmol, 25 mg), NaOtBu (1.4 mmol, 134 mg), and toluene (0.11 M with 3-bromopyridine, 9 ml) is heated to 70° C. under nitrogen until 2 is consumed. The reaction is then cooled to room temperature, and taken up in 10 ml diethyl ether, washed 3 times with 10 ml saturated brine, dried over MgSO4, and condensed in vacuo . The crude product is purified by flash chromatography to afford 3.

出典