反応 #362830

反応方程式

(S)-N-tert-butoxycarbonyl-4-O-(2-chloroethyl)tyrosine

→

(S)-4-O-(2-chloroethyl)tyrosine hydrochloride

収率 77.6%

溶媒

dioxane

反応条件

後処理

1. 1
   その他are placed in a round-bottomed flask
2. 2
   濃縮the mixture is concentrated to dryness under reduced pressure
3. 3
   workup.STIRRINGthis solution is then stirred
4. 4
   ろ過filtered
5. 5
   洗浄The resulting solid is washed with 2 times 25 ml of ether
6. 6
   その他dried under reduced pressure in order

実験手順

5 g of (S)-N-tert-butoxycarbonyl-4-O-(2-chloroethyl)tyrosine, dissolved in 50 ml of hydrochloric dioxane, are placed in a round-bottomed flask. After having been stirred for 28 h, the mixture is concentrated to dryness under reduced pressure. The resulting residue is taken up in 50 ml of ether and this solution is then stirred and filtered. The resulting solid is washed with 2 times 25 ml of ether and then dried under reduced pressure in order to yield 1.58 g of (S)-4-O-(2-chloroethyl)tyrosine hydrochloride in the form of a white solid which melts at 260° C.

出典