反応 #3624

反応方程式

4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline

hydrazine

→

desired product

4,5-Dihydro-5(4-aminobenzoyl)pyrrolo[1,2-a]quinoxaline

溶媒

ethyl alcohol

反応条件

後処理

1. 1
   温度heating
2. 2
   温度under reflux for 2 hours
3. 3
   ろ過The hot reaction mixture is filtered through diatomaceous earth
4. 4
   洗浄the filter cake washed with hot chloroform
5. 5
   濃縮the filtrate concentrated in vacuo
6. 6
   その他The residue is triturated with ethyl acetate
7. 7
   ろ過the mixture filtered

実験手順

To a solution of 1 mmol of 4,5-dihydro-5-(4-nitrobenzoyl)pyrrolo[1,2-a]quinoxaline in 20 ml of ethyl alcohol is added 0.2 g of 10% Pd/C and 2.5 mmol of hydrazine followed by stirring and heating under reflux for 2 hours. The hot reaction mixture is filtered through diatomaceous earth and the filter cake washed with hot chloroform and the filtrate concentrated in vacuo. The residue is triturated with ethyl acetate and the mixture filtered to give the desired product as crystals, m.p. 225°-228° C.

出典