反応 #361289

反応方程式

toluene

SOCl2

furanoic acid

1,2-dimethoxyethane

ammonia

→

white crystals

2-(4-methylphenyl)furan-3-carboxamide

反応条件

後処理

1. 1
   温度The mixture is refluxed for 3 h
2. 2
   workup.DISTILLATIONthe excess SOCl2 and the toluene are then distilled
3. 3
   その他to give an oil, which
4. 4
   ろ過The precipitate is filtered off
5. 5
   洗浄washed with water

実験手順

20 ml of SOCl2 are added to a solution of 13.4 g of the furanoic acid prepared above in 70 ml of toluene. The mixture is refluxed for 3 h and the excess SOCl2 and the toluene are then distilled to give an oil, which is reacted at 5° C. with a solution of 100 ml of 1,2-dimethoxyethane saturated with ammonia. The precipitate is filtered off and washed with water and then with isopropyl alcohol to give 7 g of white crystals of amide.

出典