反応 #3611
ord-ad1ac3ae5a894c42a369e1a0f5415105
反応方程式
o-trifluoromethylbenzoic acid
thionyl chloride
→
desired product
2-(Trifluoromethyl)benzoyl chloride
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度at reflux for 1 hour
- 2その他The volatiles are evaporated in vacuo
- 3その他to give a residue which
- 4濃縮is concentrated from toluene three times
- 5その他dried under vacuum
実験手順
A solution of 2.0 g of o-trifluoromethylbenzoic acid in 21 ml of thionyl chloride is heated at reflux for 1 hour. The volatiles are evaporated in vacuo to give a residue which is concentrated from toluene three times and dried under vacuum to give 2.1 g of the desired product as a residue.