反応 #360843

反応方程式

HCl

2-Acetylfuran

dimethylamine hydrochloride

paraformaldehyde

→

crystals

収率 13.0%

N,N-dimethyl-2-(2-furoyl)ethylamine hydrochloride

収率 13.0%

溶媒

ethanol

反応条件

後処理

1. 1
   その他was pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;)
2. 2
   その他the hot product collected in an ice-water cooled flask

実験手順

2-Acetylfuran (13.8 g), dimethylamine hydrochloride (13.3 g), paraformaldehyde (5.0 g) and ethanol (80 ml) acidified with concentrated HCl (1.0 ml) were stirred. Part of this mixture (27 ml) was pumped through the CMR (18 ml/min; 160°-70° C.; 500 kPa;) and the hot product collected in an ice-water cooled flask, to afford pale yellow crystals m.p. 172.5°-173° C. (cf lit.10 m.p. 173°-4° C.) in 13% yield.

出典