反応 #3607

反応方程式

3-methylbenzo[b]thiophene-2-acetic acid

thionyl chloride

→

desired product

3-Methylbenzo[b]thiophene-2-acetyl chloride

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度at reflux for 1 hour
3. 3
   その他The volatiles are evaporated in vacuo
4. 4
   その他to give a residue which
5. 5
   濃縮is concentrated from toluene three times
6. 6
   その他dried under vacuum

実験手順

A mixture of 2.0 g of 3-methylbenzo[b]thiophene-2-acetic acid and 19.4 ml of thionyl chloride is heated at reflux for 1 hour. The volatiles are evaporated in vacuo to give a residue which is concentrated from toluene three times and dried under vacuum to give 2.25 g of the desired product as a residue.

出典