反応 #3600

反応方程式

3-chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

triethylamine

2-methylbenzoylchloride

→

N-[4-(3-Chloro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]-2-methylbenzamide

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄The mixture is washed with water, and 1M NaHCO3 and dried(Na2 SO4)
2. 2
   その他The solvent is removed in vacuo
3. 3
   その他to give a solid which
4. 4
   その他is recrystallized from dichloromethane-hexane
5. 5
   その他to give crystals, 185°-187° C.

実験手順

A mixture of 1 mmol of 3-chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 2 mmol of triethylamine, and 1.1 mmol of 2-methylbenzoylchloride in 8 ml of dichloromethane is stirred at room temperature overnight. The mixture is washed with water, and 1M NaHCO3 and dried(Na2 SO4). The solvent is removed in vacuo to give a solid which is recrystallized from dichloromethane-hexane to give crystals, 185°-187° C.

出典