反応 #3599

反応方程式

3-chloro-10,11-dihydro-10-(4-nitroaminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

hydrazine

→

desired product

3-Chloro-10,11-dihydro-10-(4-aminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

溶媒

ethyl alcohol

反応条件

後処理

1. 1
   温度is refluxed for 1.5 hours
2. 2
   ろ過The mixture is filtered through diatomaceous earth
3. 3
   濃縮the filtrate concentrated to dryness

実験手順

A mixture of 1 mmol of 3-chloro-10,11-dihydro-10-(4-nitroaminobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine, 2.5 mmol of anhydrous hydrazine, 50 mg of palladium on carbon and 10 ml of ethyl alcohol is refluxed for 1.5 hours. The mixture is filtered through diatomaceous earth and the filtrate concentrated to dryness to give the desired product as a solid.

出典