反応 #359821

反応方程式

2,4-Dichloro-5-ethyl-pyrimidine

triethylamine

(R)-2-Amino-3-methyl-butan-1-ol

→

product

収率 60.9%

(R)-2-(2-Chloro-5-ethyl-pyrimidin-4-ylamino)-3-methyl-butan-1-ol

収率 60.9%

溶媒

acetonitrile

反応条件

後処理

1. 1
   濃縮is finally concentrated by evaporation
2. 2
   その他The remaining residue is purified by chromatography (DCM/EtOH 90:10)

実験手順

A solution of 882 mg (5.0 mmol) of 2,4-Dichloro-5-ethyl-pyrimidine and 0.75 ml (5.5 mmol) triethylamine in 5 ml of acetonitrile is mixed with 672 mg (6.5 mmol) of (R)-2-Amino-3-methyl-butan-1-ol. The batch is stirred at room temperature for 16 hours and is finally concentrated by evaporation. The remaining residue is purified by chromatography (DCM/EtOH 90:10). 742 mg of the product is obtained that still contains considerable amounts of (R)-2-Amino-3-methyl-butan-1-ol. The material is used without further purifications.

出典